Fig. 1. The effect of bicuculline on Aβ-, Aδ-, and C-fiber–evoked activity (16 stimuli of 3 × C-fiber threshold, 0.5 Hz, 2-ms-wide pulse) and postdischarge (PD) of a population of dorsal horn neurons in rats with spinal nerve ligation–induced neuropathy (circles) and sham-operated (triangles) and nonoperated control animals (squares). Mean of the effect achieved 20 min after intrathecal administration of bicuculline (± SEM) is plotted against the respective dose. In the spinal nerve ligation group, 7 cells were recorded after 0.5 μg bicuculline, 10 after 5 μg bicuculline, and 10 after 50 μg bicuculline. In the sham-operated control group, n = 9, 12, and 10, respectively, and in the nonoperated control group, n = 7, 9, and 8, respectively. Asterisk indicates statistically significant difference between the study groups.