Fig. 7. During the condition of immediately complete mixing in the central compartment at a wide range of infusion rates (10–450 mg · kg−1· h−1), effect-site propofol concentrations at loss of consciousness at various infusion rates were calculated with effective induction dose (effective induction dose = total induction dose − 60 s for residual dosecirculationfor undiluted or 40 s for residual dosecirculationfor diluted propofol) with previous pharmacokinetic pharmacodynamic parameters. 9,10