Fig. 2. Differential effects of nitrous oxide and xenon on ligand-gated ion channels. The effects of nitrous oxide (0.58 atm) and xenon (0.46 atm) on the current responses of α¹glycine (Gly) and α¹β²γ^2SGABA^Areceptors to EC⁵(concentrations giving 5% of the maximal response) concentrations of glycine and GABA, respectively (n = 8–15); responses of NR1a/2A NMDA receptors to 2 μm l-glutamate plus 10 μm glycine (n = 11–15); responses of α4β2 and α4β4 nACh receptors to 3 and 10 μm acetylcholine, respectively (n = 5–15). Effects of 100% nitrogen are also shown as a control for hypoxia (n = 4–6).