Table 1. Pharmacokinetic Parameters

The parameters are derived from a mixed-effects model fit of the pharmacokinetic data to the model: conc = (Ae^{−α(t−δ)}+ Be^{−β(t−δ)}+ Ce^{−γ(t−δ)}) × u(t −δ) where u(t −δ) is defined to be 0 for times t < δ and 1 for times t ≥δ. The coefficients A, B, and C are normalized to a dose of 1 mg. Values in parentheses represent the standard error of the parameter estimates. These parameters may be used to predict plasma concentrations that result from the administration of doses other than 1 mg by multiplying the administered dose by the coefficients for the specific model.