Fig. 2. (A ) The arterial plasma concentrations of morphine after inhalation (solid circles and line) and intravenous (open circles and dashed line) administration in the subjects administered the higher dose. The lines represent the best fit derived from the pharmacokinetic model. Each point is the mean ± SD. Error bars are omitted from the earlier time points for clarity and are shown for these time points in B . (B ) The time course of A  is expanded to show in detail the absorption and early distribution phases of morphine disposition after inhalation (solid circles and line) and intravenous (open circles and dashed line) administration in the subjects administered the higher dose. The lines represent the best fit derived from the pharmacokinetic model. Each point is the mean ± SD.