Fig. 4. Different stages of nerve cell damage in the cerebral cortex of a septic pig: Reversible damaged neurons (e.g. , medium arrows) with clumped substance of Nissl (cromatolysis) are next to undamaged (e.g. , small arrows) and irreversible damaged (e.g. , large arrow) neurons. The cell body of irreversible damaged neurons is shrunken and displays intensively eosinophilic cytoplasm; the nucleus is pycotic and lacks discernible nucleolus. The perineuronal spaces are exceptionally prominent. Hematoxylin and eosin staining: magnification × 880 (A ), 1,320 (B ).