Fig. 5. Enflurane depressed synaptic potentials in mouse motor neurons under current clamp. (A ) Sample records of excitatory postsynaptic potentials (EPSPs) that were evoked by stimulation in the dorsal horn area. Exposure to one minimum alveolar anesthetic concentration of enflurane for 10 min decreased EPSP size, and the depressant effect was reversible after washout. EPSPs were an average of five consecutive responses. (B,C ) Time courses of EPSP amplitude and area, respectively, recorded from the same cell as in (A ). (D ) Enflurane decreased the amplitude and area of evoked EPSPs, with insignificant changes of membrane resistance.