Fig. 5. Concentration–response curves to sodium nitroprusside and NOC-7 in the presence of glibenclamide (10−5M) or in the presence of glibenclamide (10−5M) plus mexiletine (3 × 10−5M), obtained in rat thoracic aortas without endothelia. Data are shown as the mean ± SEM and expressed as percent of maximal relaxation induced by papaverine (3 × 10−4M; 100%= 703 ± 80 mg [n = 7] and 669 ± 63 mg[n = 7] for rings of sodium nitroprusside treated with glibenclamide, or glibenclamide plus mexiletine; 100%= 1,224 ± 74 mg [n = 5] and 1,076 ± 85 mg[n = 5] for rings of NOC-7 treated with glibenclamide, or glibenclamide plus mexiletine, respectively).