Fig. 3. Isoflurane preferentially depressed the amplitude of fEPSPs mediated by NMDA receptors (bottom ) compared with non-NMDA fEPSPs (top ). This selective effect was significantly larger than that observed for non-NMDA fEPSPs (P < 0.001, ANOVA). Note that isoflurane has a faster onset and slower recovery phase of NMDA fEPSPs than those for non-NMDA fEPSPs. Each data point represents the mean ± SD from five experiments, each from different slices.