Fig. 2. Halothane decreases fEPSP amplitudes mediated by non-NMDA receptors (top ) and NMDA receptors (bottom ) to a similar degree. Graphs of fEPSP amplitudes vs.  experimental time show the halothane-induced depression of fEPSP amplitudes observed for non-NMDA and NMDA receptor–mediated responses. Each data point represents the mean ± SD from five experiments using separate slice preparations for NMDA responses and seven for non-NMDA responses. All amplitudes were expressed as a percent of average of control recordings taken during the 10 min preceding application of the anesthetic agent. Note that the time course of the effects of halothane on NMDA fEPSPs appeared to be faster than that for non-NMDA–mediated responses.