Fig. 1. Flow of the study in one subject (volunteer no. 1) whose core temperature was 34.3°C. Vecuronium plasma concentrations are represented by the filled circles and dashed line, whereas those of the metabolite 3-desacetylvecuronium are represented by open circles and dashed line. The solid line indicates twitch tension of the adductor pollicis (as a fraction of prevecuronium control).