Fig. 3. Inhibition of kainate-evoked currents by pentobarbital. The application of various concentrations of pentobarbital (0, 30, 100, 300, 1,000, and 3,000 μM) are shown for current activated by 300 μM kainate in (  A ) wild-type (+/+) neurons and by 150 μM kainate in (  B ) mutant (−/−) neurons. Kainate was applied as indicated by the solid bar before, during, and after the application of pentobarbital.