Figure 5. Time-effect curves for S(+)ibuprofen and R(-)ibuprofen in the formalin test. S(+)ibuprofen means S(+)ibuprofen 1,000 [micro sign]g and R(-)ibuprofen means R(-)ibuprofen 1,000 [micro sign]g. Each drug was administered 10 min before the formalin injection. Each symbol shows mean +/- SD of the total numbers of s for which the paw was kept raised per min in five to seven animals. The data points were obtained as described in Materials and Methods. *P < 0.05;**P < 0.01;***P < 0.001 versus control value at same time-point (ANOVA and Bonferroni-Dunn post hoc test). The group administered S(+)ibuprofen had a statistically significant difference (P < 0.001) with the control group in the data during 15–65 min (ANOVA for repeated measures).