Fig. 8. Percentage change of mean pulmonary arterial pressdure and systemic arterial pressure (SAP) during inhalation of nitric oxide (NO; 5 and 20 ppm), aerosolized zaprinast (ZAP, 10–50 mg/ml), or both, in awake lambs. *Significantly different from values at pulmonary arterial hypertension (  P < 0.05). #Significantly different from the value at 5 ppm NO (  P < 0.05) and from 10 mg/ml zaprinast (  P < 0.01). Values are mean ± SD. Reprinted with permission from Ichinose  et al. 302