Fig. 7. Influence of continuous intravenous zaprinast infusion (0.1 mg · kg−1· min−1) on the magnitude of peak decreases of mean pulmonary arterial pressure ( A ), percent changes of pulmonary vascular resistance ( B ), and half-times of vasodilating effects ( C ) in response to nitric oxide inhalation during pulmonary arterial hypertension induced by U46619 in awake lambs. Values are mean ± SE. *Significantly different from control value ( P < 0.05). Reprinted with permission from Ichinose et al. 302
