Figure 1. Blood levels of prothrombin F1+2 (F1+2) during hybrid total hip replacement. Significant increases in F1+2 occurred during surgery on the femur. Values for F1+2 were significantly lower in the 20-U/kg heparin group than the saline group during surgery on the femur. Values are mean +/− SD. *P = 0.03 compared with 20 U/kg. [dagger] P = 0.001 compared with 20 U/kg. [double dagger] P = 0.04 compared with 20 U/kg.