Figure 3. Histologic evidence of corticomedullary necrosis after the administration of mercapturates or glutathione conjugates of compound A to Wistar rats. (A) Kidney section of a control rat. (B) Kidney section of a rat 24 h after intraperitoneal treatment with mercapturates of compound A (180 [micro sign]mol/kg). (C) Same as B, except that the rat was pretreated with aminooxyacetic acid (500 [micro sign]mol/kg given intraperitoneally) 1 h before the administration of the mercapturates. (D) Same as B, except that the rat was pretreated with acivicin (250 [micro sign]mol/kg given intraperitoneally) 1 h before the administration of the mercapturates. (E) Kidney section of a rat 24 h after intraperitoneal treatment with glutathione conjugates of compound A (180 [micro sign]mol/kg). (F) Same as E, except that the rat was pretreated with acivicin (250 [micro sign]mol/kg given intraperitoneally). The sections were stained with hematoxylin and eosin.