![Figure 9. The effects of diazepam on depolarization-induced whole-cell outward K+current (IK) with a pipette solution including no CaCl (2) and 10 mM EGTA. (A) Typical recordings of IKinduced by pulses up to +60 mV in the absence and presence of 10-4M diazepam. The dashed line denotes no current. (B) Relative peak current-voltage relations obtained before and after exposure to 10-4M diazepam. (C) The relation between peak IKat +60 mV, expressed as a percentage of control, and the bath concentrations of the benzodiazepines diazepam ([black circle], solid line) and midazolam ([black square], dashed line). Symbols represent the mean +/− SD (n = 7). *P < 0.05, percentage comparison of control of peak IKwithout agents.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/90/1/10.1097_00000542-199901000-00026/2/26ff9.png?Expires=1716272705&Signature=DSUyS1Hd3jv-ZxsXrLp1mliFLnx8z9U2Z2KBoiqRlfkDS0WVgGcFx2bMJiEaQI66RbwcqPLFTabTTDWNDBNpRVyGH4gNzXpE1TcC6CKfohVQeuXm9eC-jRMM4fJg4Wkrw-R3HM87vgeD5uOJ3osePTx1~g-S8A6aSEM16lwQtGn7vYY1jAtHzZ2H9psYad1Rx4TF5ZqbnkpzO-aE4vbiaxvnqvF-3JtKm02iiq8hjGAPWgpAg1C1Ib-De7sKPnfvEkE-eZT1vi3slZmCsDPAo-4Z0RCMMRJRuSm6iTMxZn7XLlMXk-ALraucmk~3DRfbvXwfGtyx7CqzdQBbj9VP8g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 9. The effects of diazepam on depolarization-induced whole-cell outward K+current (IK) with a pipette solution including no CaCl (2) and 10 mM EGTA. (A) Typical recordings of IKinduced by pulses up to +60 mV in the absence and presence of 10-4M diazepam. The dashed line denotes no current. (B) Relative peak current-voltage relations obtained before and after exposure to 10-4M diazepam. (C) The relation between peak IKat +60 mV, expressed as a percentage of control, and the bath concentrations of the benzodiazepines diazepam ([black circle], solid line) and midazolam ([black square], dashed line). Symbols represent the mean +/− SD (n = 7). *P < 0.05, percentage comparison of control of peak IKwithout agents.
