![Figure 6. A computer simulation of a typical remifentanil "balanced" anesthetic (i.e., remifentanil in combination with nitrous oxide, inhaled vapor, or propofol) when the dosage regimen is calculated based on LBM or TBW for both obese and lean patients (1 [micro sign]g/kg bolus injection followed by an infusion of 0.5 [micro sign]g [middle dot] kg-1[middle dot] min (-1) for 15 min and 0.25 [micro sign]g [middle dot] kg-1[middle dot] min-1for an additional 105 min). Note that TBW-based dosing in an obese patient results in dramatically higher concentrations.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/89/3/10.1097_00000542-199809000-00004/2/4ff6.png?Expires=1716318549&Signature=PWdFolU9FaH80UH1pzmyviTh~iRb~aOvvcSMAfT5Ovi1~ErASkUX3oJFzo9rhC4Z7tCU2ffnQcS5UslA-90CGR53rcLvA7SKpCS~jnKqiXN29lC5P7xrcvwCLRq6fP2Kk-pHVIws5e652lQ3hTnalRHypDsbkWrprGKklOdNh3hM6TjRhwXIbkI8j8bx4HfR98~earP1qHVZhJVqGVi0EAbGa0lP7ibYVg44WLayZObBgoQCqu5TpOkAyz38ngcAuKB5Zf1kyJDEUomAgllgRi6PT9sWguQ19CwVEcfO2CF0P2QoVDeL5vVlzJ2iEIufDqlaMjQMt~ke-VcD0a4iwA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 6. A computer simulation of a typical remifentanil "balanced" anesthetic (i.e., remifentanil in combination with nitrous oxide, inhaled vapor, or propofol) when the dosage regimen is calculated based on LBM or TBW for both obese and lean patients (1 [micro sign]g/kg bolus injection followed by an infusion of 0.5 [micro sign]g [middle dot] kg-1[middle dot] min (-1) for 15 min and 0.25 [micro sign]g [middle dot] kg-1[middle dot] min-1for an additional 105 min). Note that TBW-based dosing in an obese patient results in dramatically higher concentrations.
