Figure 3. Capsaicin-evoked allodynia and hyperalgesia. Areas of (A) allodynia and (B) hyperalgesia are plotted as percentages of baseline, defined as the area determined 5 min after injection of intradermal capsaicin. Mean areas of allodynia from 10 to 60 min after capsaicin were significantly less for both 33%MTD and 100%MTD. A trend toward a reduction of the area of pinprick hyperalgesia was not statistically significant. Mapping of allodynia and pinprick hyperalgesia at each time point began at the time indicated and took 1 or 2 min. Therefore, the 10-min point, which already shows the effects of the drug infusion begun at 10 min, indicates that the drug already has some effect within 2 min of starting LY293558.