Figure 1. (A) Heat pain thresholds (means and SD) and (B) heat pain responses to 45 [degree sign]C (means and SD, B) in burns. Pain was assessed with a visual analog scale (VAS 0–100) on which verbal descriptors were added (weak pain, 2%; mild pain, 8%; moderate pain, 18%; strong pain, 39%; and intense pain, 74%). [10,11]Heat pain thresholds in healthy and inflamed skin immediately after burn were significantly increased by local subcutaneous infiltration with ketamine compared with placebo (healthy skin, P = 0.03; inflamed skin, P = 0.02 by Student's t test). Suprathreshold heat pain responses were not reduced by local ketamine. The analgesia lasted <1 h.