Figure 2. Rats were subjected to bilateral carotid occlusion combined with systemic hypotension for different intervals (10 min, 14 min, or 6 min) with pericranial temperature held at 31 [degree sign]C or 37 [degree sign] Celsius. Seven days later, the percentage of dead hippocampal CA1 neurons was determined. Open circles depict values for the eight individual rats in each group. Open rectangles depict mean values for each group. Rats in the 6 min-37 [degree sign]C group were not studied concurrently and are provided for visual comparison only. Increasing the duration of ischemia from 10 to 14 min did not increase injury during hypothermia. S = significant (median difference, 55–90%); NS = not significant (median difference, -1% to 3%).