Figure 7. Lemakalim dose-response relationship measured in six dogs after preconstriction with U46619 in the conscious state and during desflurane anesthesia. Vasodilator response to lemakalim is expressed as the percent decrease in preconstriction with U46619 (defined in methods). The attenuated ((dagger)P < 0.05) lemakalim-induced pulmonary vasodilation (*P < 0.05) during desflurane anesthesia was largely reversed after pretreatment with prazosin.