Figure 2. Composite left pulmonary vascular pressure-flow (LPQ) plots in six dogs at baseline, after preconstriction with U46619, and during administration of lemakalim (1.0 micro gram [center dot] kg sup -1 [center dot] min sup -1 intravenously) in the conscious state (top) and during sevoflurane anesthesia (bottom). In the conscious state and during anesthesia with sevoflurane, this dose of lemakalim caused a rightward shift in the LPQ relationship, indicating pulmonary vasodilation.