Figure 3. Time-dependent inhibition of alfentanil elimination by troleandomycin. The main figure shows alfentanil (20 micro gram/kg) disposition in a man treated with troleandomycin. Symbols depict measured concentrations, and lines represent predicted concentrations using parameters derived from a three-compartment model incorporating the time-dependent parameter k¹⁰(t). The inset shows the time-dependent value of k¹⁰(t).