Figure 3. Influence of ketamine on 2,4-dinitrophenol (DNP)-induced opening of KATPchannels in cell-attached patches. DNP in the bath solution activated KATPchannels, and ketamine inhibited the DNP-induced effect in a concentration-dependent manner. (A) A representative tracing in which ketamine inhibits the DNP-induced opening of KATPchannels. (B) The averaged relative channel activity from 12 observations obtained under the same experimental conditions as in Figure 3(A). Results are presented as means +/- SD. *Significantly different from control (P < 0.05). Other information is the same as in Figure 1.