Figure 2. Effect of ketamine on pinacidil-induced opening of KATPchannels in cell-attached patches. Pinacidil in the bath solution activated KATPchannel activity, and ketamine inhibited this effect of pinacidil in a concentration-dependent manner. (A) A representative tracing in which the inhibitory effect of ketamine on the pinacidil-induced KATPchannel activity. (B) The averaged relative channel activity from 12 observations obtained under the same experimental conditions as in panel A. Results are presented as means +/- SD. *Significantly different from control (P < 0.05). Other information is the same as in Figure 1.