![Figure 5. Effect of ketamine on intracellular concentrations of cyclic adenosine monophosphate ([cAMP]i) and guanosine monophosphate ([cGMP]i). There was no effect of ketamine in canine smooth muscle strips (n = 7) incubated with 10 micro Meter indomethacin and contracted with 0.1 micro Meter acetylcholine on [cAMP]iand [cGMP]i. In canine smooth muscle strips (n = 6) incubated with 10 micro Meter indomethacin and contracted with 0.1 micro Meter acetylcholine, 10 micro Meter isoproterenol caused a significant increase in [cAMP]i, and served as a positive control. *Significant difference from baseline (t test, n = 6). Values are means +/- standard deviations.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/86/5/10.1097_00000542-199705000-00014/2/14ff5.png?Expires=1716430175&Signature=tvdwSDveZet8ZDH1DIaU9Loc~A7XSGGpE9vnfm7xWcpPWpzRsX2zIpP7VYcrRYr0Yq752umWYVXsPXeHy4L6ftwVrfdlaFWXcyNRQwsb7p2n3MOVrKlURAv-XShOBpNmckwGdOXj-~MlYSBXt~bFRpFL2LT-89OEePXinHq8FidKWAQv1qjtknxHXt38FGHDOT7WnOMfJNiMnK0cpPE0taOj~4~7gl57~3~b-BPXFlfmIpp4zEMnyVjfabyR6c0V2rc7tHciXrKwxX6jMv94M2I4hOemhh~vj3rL3EI2Jy-BOh7Qn9oV5xVH35-UYU0UxK5ClaIRJQ2K~pe~ztUOEg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 5. Effect of ketamine on intracellular concentrations of cyclic adenosine monophosphate ([cAMP]i) and guanosine monophosphate ([cGMP]i). There was no effect of ketamine in canine smooth muscle strips (n = 7) incubated with 10 micro Meter indomethacin and contracted with 0.1 micro Meter acetylcholine on [cAMP]iand [cGMP]i. In canine smooth muscle strips (n = 6) incubated with 10 micro Meter indomethacin and contracted with 0.1 micro Meter acetylcholine, 10 micro Meter isoproterenol caused a significant increase in [cAMP]i, and served as a positive control. *Significant difference from baseline (t test, n = 6). Values are means +/- standard deviations.
