Figure 3. Changes in mean arterial pressure (left) and cardiac index (right) before and after intravenous bolus injections of heparin at 300 units/kg and a reversing agent. The reversing agents were: heparinase I (Neutralase) at 0.625, 1.25, 2.5, or 5 IU/kg, vehicle (0.125 ml/kg, a volume equivalent to that of 2.5 IU/kg), and protamine (3.9 mg/kg). Results are presented as mean values. (dagger)P < 0.05, (double dagger)P < 0.01, compared to the concurrent values of the vehicle group. For clarification, values at 60 min, which are statistically similar among all treatment groups, are not shown.