Figure 4. The minute ventilation versus time data for the subjects with liver disease (A) and the control subjects (B). Each dashed line represents the data from one subject, and the heavy lines are the mean values. In all groups, minute ventilation declined during the first hour of the infusion, and a further decline occurred during the subsequent 3 h of the infusion after the infusion rate was doubled. Minute ventilation returned rapidly to baseline after the infusion was terminated.