Figure 3. For the semiparametric approach, pharmacokinetic and pharmacodynamic data from the same participant as in Figure 1are shown. The volunteer received 60 micro gram/kg vecuronium at time 0. The upper panel shows values for measured plasma concentrations of vecuronium (filled triangles) and 3-desacetylvecuronium (open triangles) and the values predicted from the semiparametric pharmacokinetic model for vecuronium (solid line) and 3-desacetylvecuronium (dotted line). The exact fit of the pharmacokinetic model to the measured plasma concentration values results from the use of linear interpolation. Measured values for twitch tension of the adductor pollicis (middle) and the laryngeal adductors (lower) are displayed as triangles; predicted values are shown by the solid line.