Figure 6. Effects of desflurane (DES), enflurane (ENF), halothane (HAL), isoflurane (ISO), and sevoflurane (SEV) on the cytochrome P450 activity of rabbit liver microsomes. *P < 0.05 versus control; **P < 0.01 versus control (n = 3 or 4). The microsomal cytochrome P450 activity in the absence of the anesthetics (0.434 plus/minus 0.031 nmol *symbol* mg sup -1 *symbol* min sup -1) was taken as 100%, and their inhibitory effect expressed as percentage of the control activity. Where no error bar is shown, SEM falls within the dimensions of the symbol.