Figure 5. Open-state dwell time constants for malignant hyperthermia (MH) mutant and wild-type channels with varying concentrations of dantrolene sodium. (A) Short dwell time constant tauO1is greater in MH mutant channel and dantrolene sodium (DS) produced greater increase in tauO1of wild-type channels. (B) Longer open time constant, tauO2was not different between MH mutant and wild-type channels, and DS effect is not significant.