![Figure 3. Intrasynaptosomal [Calcium2+] ([Ca2+]i) and the glutamate release in response to KCl depolarization in the presence of varied [Calcium2+] in the external medium ([Ca2+]e). (A) Changes in [Ca2+]ifrom one synaptosomal preparation in the presence of the varying [Ca2+]eindicated. (B) The dependence of the net [Ca2+]itransient on [Ca2+]e(ext[Ca]). Each point represents the mean of three to five measurements. (C) Changes in nicotinamide adenine dinucleotide phosphate (NADPH) fluorescence intensity (FI) representing glutamate release with varied [Ca2+]e, in which the decreased slope of the FI increase is proportional to the magnitude of glutamate release. (D) Fractional change in the Calcium2+ transient and glutamate release plotted as a fraction of the control level observed in presence of 1.3 mM [Ca2+]e.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/83/3/10.1097_00000542-199509000-00019/2/19ff3.png?Expires=1716498934&Signature=jvVRlZDvIvzmcGvdkR5haWg01PrzuszNPatOyqJHGcT8dv6Sa3BEI3H3nJxHNd~BEPPWkm8IRzANhYPDjpPKc43ONdeprB~5QSjvo-x7o5FnpKEE1QEPKs2ek~oNvnvoszKCwOc77iBvLVkqhqV8pzuOiDXxmfTyuD6UwevdB511iyGWP-VAEDZbc0sqls7xsbwoBCTQASUd3OmgmoLLt~B959JAvrsrGs83UZxgJnjpC61zB5Kf1M698Mhm5mjvHzmLrID5X5yt6hDdRuW0FWe9LJddl8vvXLJV0RMZ3DYkyKgVgSBqcixaBbLqKejnQitlWanGoj9cVbkmjRHBfQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 3. Intrasynaptosomal [Calcium2+] ([Ca2+]i) and the glutamate release in response to KCl depolarization in the presence of varied [Calcium2+] in the external medium ([Ca2+]e). (A) Changes in [Ca2+]ifrom one synaptosomal preparation in the presence of the varying [Ca2+]eindicated. (B) The dependence of the net [Ca2+]itransient on [Ca2+]e(ext[Ca]). Each point represents the mean of three to five measurements. (C) Changes in nicotinamide adenine dinucleotide phosphate (NADPH) fluorescence intensity (FI) representing glutamate release with varied [Ca2+]e, in which the decreased slope of the FI increase is proportional to the magnitude of glutamate release. (D) Fractional change in the Calcium2+ transient and glutamate release plotted as a fraction of the control level observed in presence of 1.3 mM [Ca2+]e.
