Figure 1. Total cytochrome P450 content decreased as plasma nitrite and nitrate concentrations increased after lipopolysaccharide injection. Data from nontreated rats (lower line) as well as rats pretreated with phenobarbital (upper line) support the concept that nitric oxide reduces functional P450 content during sepsis. Each data point (symbol) represents the mean of appropriate duplicates from one rat liver (n = 48).