Figure 5. Summary of the average depressant effects of 1.2 mM halothane and 1 mM isoflurane on peak Na sup + current. Data are shown in the absence and presence of intracellular GDP beta S or PKI-(6–22)-amide. Error bars denote SEM. Reductions in INaamplitude shown are significantly different compared with control, at n = 6 to 12 cells per experimental set. * Significantly different versus halothane without inhibitor;+ significantly different versus isoflurane plus GDP beta S. There is no significant difference between the depressant effect of isoflurane in the absence or presence of PKI.