Figure 3. Summary of the inhibition of Na sup + current by isoproterenol (1 micro Meter, panel A) and forskolin (5 micro Meter, panel B) alone and in the presence of anesthetics. In combination with halothane or isoflurane, the reduction of I^Naby either isoproterenol or forskolin was measured after maximal anesthetic effect. The effects on I^Naby isoproterenol and forskolin without anesthetics were measured from control (anesthetic free). Data were obtained from the experiments described in Figure 1and Figure 2. Average values (means +/- SEM) from 9 to 12 cells per experimental set are shown. * Significantly different from steady-state I^Naamplitude after halothane exposure;+ significantly different from steady-state I^Naamplitude after isoflurane exposure;$ significantly different from isoproterenol in combination with halothane;# significantly different from control (anesthetic free). P <0.05 was considered significant.