Figure 5. Modified Schild plot showing competitive inhibition with propofol. (A) A K1determined by plotting the voltage-clamp results for propofol inhibition displayed in Figure 4, with a modified Schild plot comparing log[ACh] with current produced at different anesthetic concentrations. (B) Modified Schild dose ratio for the binding of two antagonist molecules (see appendix for derivation):(3r2/1 + 2r - 1) versus [propofol]. Fitting equation, Equation 1.