![Figure 3. Modified Schild plot showing competitive inhibition with isoflurane. (A) A K1was determined by plotting the voltage-clamp results for isoflurane inhibition as in Figure 2, with a modified Schild plot comparing log [ACh] to current produced at different anesthetic concentrations. (B) Modification of Schild's dose ratio for the binding of a single antagonist molecule, where Log (3r2/1 + 2r - 1) is plotted versus log [isoflurane](see appendix for derivation). 3r2/1 + 2r = 1 +[iso]/K1, K1= 11 micro Meter. Chi square = 0.0045.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/86/4/10.1097_00000542-199704000-00016/2/16ff3.png?Expires=1716630877&Signature=JYhB1h3E5~b47z9q6EBxDqmMeX0MywCzKQTJk3CD3xv6LPBtevKa1nZPldvLk0fjOCK1-oEc8FlF1pdG39Ih4nL63LbNNM-Gz8~XTdbMYQNVz1iGCnB9rnX-6Wj-lt~GmI2sHA4YxVbaeOVKkuBukpdPJdk4fIGVpVKe~0KN-eq9ceKx~CbLdJo-4JwzYI8dpM~yHfYJA5oseAhe88ks-WPclZrPUgr8YxFdMAq2StwAvOWdbzk44-H9OkcXoP2UyXtxPoGGrNcEBcRiKFekRvvXybMmSSthm~tNDS9A2PpqdmE9DELei06QBzDmGYYgHyqn1F0p3euLPX7wSls4oQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 3. Modified Schild plot showing competitive inhibition with isoflurane. (A) A K1was determined by plotting the voltage-clamp results for isoflurane inhibition as in Figure 2, with a modified Schild plot comparing log [ACh] to current produced at different anesthetic concentrations. (B) Modification of Schild's dose ratio for the binding of a single antagonist molecule, where Log (3r2/1 + 2r - 1) is plotted versus log [isoflurane](see appendix for derivation). 3r2/1 + 2r = 1 +[iso]/K1, K1= 11 micro Meter. Chi square = 0.0045.
