Figure 9. Effects of cumulative application (0.5–4.0%) of halothane, isoflurane, and enflurane on (A) 3 micro Meter ([nearly equal] EC⁵⁰) and (B) 30 micro Meter (maximal) Calcium²+-activated contractions in beta-escin-permeabilized strips. Each anesthetic was cumulatively applied to the strips for a period of 2 min at each concentration after the Calcium²+-activated contraction reached a plateau (5 min). All values are mean plus/minus SEM (n = 6–10, six to eight animals). *P < 0.05 versus time control (open circles) at each time point.