Fig. 6.
Log-likelihood profile (green curve) of the parameter indicating the possible fractional difference between effect site concentration at half-maximal depression of minute ventilation (Ce50) in obstructive sleep apnea (OSA) and control participants. Black vertical dotted line indicates 0, whereas red and blue horizontal solid lines represent the estimated 99% and 95% CIs, respectively. Based on the study observations, nonlinear mixed-effects modeling estimated with high confidence that Ce50 for remifentanil-induced ventilatory depression is greater in OSA than controls by approximately 7% (99% CI, −5 to 21). Obj, objective.