Fig. 2.
Ventilation, Axl inhibition and expression of suppressor of cytokine signaling (SOCS) and cytokines. In ventilated murine lungs, Axl blockade with R428 suppressed lung tissue SOCS3 upregulation; SOCS1 was not affected (A and B, one-way ANOVA). Tissue cytokine messenger RNAs for interleukin (IL)–6 (C, ANOVA on ranks) and IL-1B (D, one-way ANOVA) were increased by ventilation. This increase was reduced in the presence of R428. *P < 0.05 versus all other groups; †P < 0.05 versus nonventilated (NV); n = 4 per group. Veh = vehicle.