Figure 5. Concentration-response curves for riluzole effect on the depolarization-evoked3H-DA release mediated by veratridine (1 micro Meter), NMDA (1 mM), and kainate (1 mM) on striatal synaptosomes. Data are expressed as mean +/- SEM and were obtained from at least four independent experiments performed in triplicate. For veratridine-, NMDA-, and kainate-induced release, Hill coefficients and IC50 values could be derived from nonlinear computerized curve fitting of the data (see Methods section).
