Figure 4. Pharmacologic characterization of the3H-DA release evoked by NMDA (1 mM), kainate (1 mM), veratridine (1 micro Meter), and nicotine (0.5 mM) from preloaded striatal synaptosomes. Data are expressed as a fractional increase from basal release. MK-801, CNQX, mecamylamine, and TTX were used at 0.1 mM, 0.1 mM, 10 micro Meter, and 0.1 micro Meter, respectively (see Methods section). KAIN = kainate; VERAT = veratridine; NICOT = nicotine; MEC = mecamylamine. *P < 0.05 ***P < 0.001 versus release obtained with agonist alone.