Figure 6. Effect of intrathecal coadministration of 300 micro gram idazoxan with 100 micro gram clonidine and intrathecal administration of 300 micro gram idazoxan on the development of thermal hyperesthesia induced by a nerve constriction injury in the pretreatment study. Clonidine (100 micro gram)-administered group (n = 11) and saline-administered group (n = 12) are presented for comparison. Each point represents the mean +/- SEM of eight rats. Ordinate = difference score (DS); abscissa = days after a nerve constriction injury. *P < 0.05 compared DS value in 100-micro gram clonidine and 300-micro gram idazoxan coadministered group with that in the 100-micro gram clonidine administered group.