Figure 5. Transition responses (mean plus/minus SEM) recorded when rapidly increasing the inspired concentration of either sevoflurane or desflurane from steady-state at 0.83 MAC to either 3% sevoflurane or 9% desflurane. This rapid change in the inspired concentration of sevoflurane triggered no untoward hemodynamic responses, whereas a similar rapid change in the inspired concentration of desflurane resulted in a doubling of sympathetic nerve activity and a significant increase in heart rate and mean arterial pressure. *Significant difference between groups at specific times; P < 0.05. (dagger)Significant interaction between groups over time (analysis of variance); P < 0.05.