Fig. 4.
Concentration dependence of INa block by lidocaine in control and diabetic dorsal root ganglia. (A) Typical INa recordings in control (CTRL) and diabetic mellitus (DM dorsal root ganglia in absence and presence of 1 to 1,000 µM lidocaine. (Inset) Voltage clamp protocol. (B) Average effects of lidocaine in control (n = 10) and DM (n = 10) dorsal root ganglia. Please note that the currents are normalized to the current before application of the drug. Solid lines indicate Hill equation fits of average data. The data are given as mean ± SD.