Fig. 4.
Sufentanil infusion rate (A) required to maintain a constant total plasma concentration of sufentanil of 0.5 ng/ml for 3 h at three different cardiac output (CO) values of 3, 5, and 7 l/min, and sufentanil cumulative doses (B) associated with the infusions rates (A). Simulations were performed with the final model parameters (table 3).