Isoflurane preconditioning improved the recovery of cardiac fnction during postischemic reperfusion in Langendorff-perfused C57BL/6 mouse hearts but not db/db mouse hearts. (A) Left ventricular end-diastolic pressure (mean ± SD). (B) Left ventricular developed pressure. (C) The maximum rate of developed pressure rise (+dp/dt). (D) The maximum rate of developed presure decreases (−dP/dt). Control = C57BL/6 mouse hearts undergoing ischemia/reperfusion injury: db/db = db/db mouse hearts undergoing ischemia/reperfusion injury; isoflurane, C57BL/6 mouse hearts treated with 1.4% isoflurane before ischemia; db/db+isoflurane = db/db mouse hearts treated with 1.4% isoflurane before ischemia. *P < 0.05 versus control groups; †P < 0.05 versus db/db groups; #P < 0.05 versus isoflurane groups (n = 8 mice/group).