Fig. 4.
Expression of biologic markers associated with inflammation (interleukin [IL]-6), alveolar pulmonary stretch (amphiregulin), epithelial cell damage (club cell protein 16 [CC16]), and endothelial cell damage (intercellular adhesion molecule [ICAM]-1). Relative gene expression was calculated as a ratio of the average gene expression levels compared with the reference gene (36B4) and expressed as fold change relative to nonventilated animals (NV). Values are medians and interquartile ranges of eight rats in each group. The comparisons among all groups were done by Bonferroni’s procedure adjusted for four comparisons (P < 0.0125). *versus NV (P < 0.0125); #versus low power/high VT (P < 0.0125); †versus high power/low VT (P < 0.0125).